• EARLY LIFE EXPOSURES AND THEIR IMPACT ON SUSCEPTIBILITY TO DISEASE

The overall goal of the Early Life Theme is to determine the impact of early life environmental exposures, such as ambient exposures (hyperoxia and PAHs), endocrine disruptors (EDCs), environmental tobacco smoke (ETS), maternal and first 1000 days diet, on human health outcomes across the life course.

Leaders:

Les Dees (TAMU)

Bhagavatula Moorthy (BCM)

  • THE MICROBIOME AS A TARGET FOR ENVIRONMENTAL EXPOSURES AND AS A MODIFIER OF RESPONSE TO ENVIRONMENTAL STRESSORS

Investigators in the Microbiome Theme work to elucidate connections between environmental stressors and microbiota diversity and function; investigate the link between microbiota and host metabolism in the context of environmental and dietary exposures; and identify causal links between microbiota and chronic diseases arising from environmental exposures.

Leaders:

Arul Jayaraman (TAMU)

Joe Petrosino (BCM)

  • CHRONIC DISEASE THAT IS IMPACTED BY ENVIRONMENTAL EXPOSURES

This Theme focuses on the influence of environmental stressors, and modifiers such as diet, on development of chronic diseases including cancer, obesity, diabetes and chronic inflammatory diseases such as Crohn’s Disease.

Leaders:

Clint Allred (AgriLife)

Steve Safe (TAMU)

  • METABOLISM AS A TARGET FOR ENVIRONMENTAL STRESSORS AND AS A MODIFIER OF RESPONSE TO ENVIRONMENTAL EXPOSURES

The Metabolism Theme provides a focal point for research on how internal and external environmental exposures alter metabolic pathways that contribute to human disease.

Leaders:

Mick Deutz (TAMU)

Tim Lightfoot (TAMU)

  • ENABLING TECHNOLOGIES TO ADVANCE ENVIRONMENTAL HEALTH RESEARCH

Studies in this Thematic Focus Area are aimed at developing new engineering tools and analytical methods spanning the molecular to the systems level, not only for exploring the biological responses to environmental exposures, but to impact health care by translating technologies to the field.

Leaders:

Gerald Cote (TAMU)

Cliff Stephan (TAMHSC)